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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Taurine
drug:
Vigabatrin
Research Papers that Mention the Interaction
“The uptake rate of [(3)H]-taurine was Na(+) and Cl(-) and concentration dependent with taurine with an apparent Vmax …±1.6pmolcm(-2)min(-1) and a Km of 24.9±15.0μM. β-alanine, nipecotic acid, gaboxadol, GABA, vigabatrin , δ-ALA … the taurine uptake rate in … dependent manner.”
Interaction of GABA-mimetics with the taurine transporter (TauT, Slc6a6) in hyperosmotic treated Caco-2, LLC-PK1 and rat renal SKPT cells.“In conclusion, the present study shows that vigabatrin was able to inhibit the uptake of taurine in intestinal and renal cell culture models.”
“ Vigabatrin … taurine in Caco-2 and MDCK cells to 34 ± 3 and 53 ± 2%, respectively, at a concentration of 30 mM. In Caco-2 cells the … under neutral pH conditions is concentration-dependent and saturable with a Km-value of 27 mM (log Km is 1.43 ± 0.09).”
“The use of taurine supplementation in tandem with vigabatrin may allow reversal of retinopathy and mitigate or slow down further deterioration.”
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