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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Taurine
drug:
Valproic Acid
Research Papers that Mention the Interaction
“In seven patients subsequently treated with divalproex sodium , CSF taurine levels decreased significantly from pretreatment baseline values.”
Cerebrospinal Fluid Analyses in Migraine Patients and Controls“Moreover, VPA leveled off glycine and aspartate, exerted no effect on glutamate, and unexpectedly reduced GABA and taurine levels.”
Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rats“At 200 mg per kilogram of valproate , brain glutamate decreased and taurine levels increased.”
“In contrast, DPA augmented the depolarization of dorsal roots produced by GABA, beta-alanine and taurine.”
“Our findings suggest that Tau protects the liver tissue against VPA toxicity via inhibiting necroptosis signaling pathway mediated by RIPK1/RIPK3/MLKL and suppressing oxidative stress, and apoptosis.”
Taurine attenuates valproic acid-induced hepatotoxicity via modulation of RIPK1/RIPK3/MLKL-mediated necroptosis signaling in mice.“Thus, it may be conclude that chronic treatment with VPA produces decreases on the endogenous levels of glutamate and taurine.”
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