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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Taurine
drug:
Ursodeoxycholate
Research Papers that Mention the Interaction
“The addition of taurine to ursodeoxycholic acid produced only minor changes in the effects of ursodeoxycholic acid alone.”
“In 9 CF patients with clinical and biochemical evidence of liver disease, taurine (30 mg/kg/day) was administered one month before and during the successive treatment with ursodeoxycholic acid (10-15 mg/kg/day).”
“ Taurine administration produced only inconsistent changes of liver function tests from baseline, whereas after the addition of ursodeoxycholic acid a substantial improvement in all abnormal indices was observed.”
“These studies show that the administration of free ursodeoxycholic acid results in the increased formation of … of 1 gm per day of tauroursodeoxycholic acid or 1.5 gm per day of taurine together … free ursodeoxycholic acid increases the excretion of tauroursodeoxycholic acid in …% of the total biliary ursodeoxycholic acid.”
“When three patients were fed 1.5 gm per day of taurine together with 750 mg per day of free ursodeoxycholic acid for 10 days, the taurine conjugation of ursodeoxycholic acid and other bile acids increased to 29 to 40%.”
The effect of tauroursodeoxycholic acid and taurine supplementation on biliary bile acid composition“If conjugation with taurine is important for the protective effect of UDC , then MUDC may not be as able as TUDC to prevent TLC-induced cholestasis since it is poorly amidated by the liver.”
Different protective effects of tauroursodeoxycholate, ursodeoxycholate, and 23-methyl-ursodeoxycholate against taurolithocholate-induced cholestasis“In rats receiving UDC and TCDC, total biliary output of LDH for 2 h was significantly higher in taurine-deprived rats than that in the control (73.40 +/- 10.10 vs 41.14 +/- 12.56: P < 0.05), suggesting that the difference became greater upon taurine deprivation.”
“On the other hand, UDCA conjugated with either glycine (GUDCA) or taurine (TUDCA), increased LDL binding to the same extent as did the free bile acid.”
“Similarly, serum taurine‐ or glycine‐conjugated ursodeoxycholic acid (UDCA) was increased significantly 2 h after UDCA administration.”
“The SRm of UDCA in the presence of a taurine infusion (1,367 +/- 84.4) was higher than that of UDCA infused alone but still much lower than that of TUDCA.”
“The percentage of biliary UDCA was higher with TUDCA (38.5 +/- 3.7) than with UDCA plus taurine (26.5 +/- 2.0, P less than 0.01).”
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