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Last Updated: 3 years ago

Possible Interaction: Taurine and Urokinase-Type Plasminogen Activator

Research Papers that Mention the Interaction

In addition serum MDA levels were significantly decreased (20.85 +/- 3.05 mumol/L vs 25.18 +/- 3.53 mumol/L after combined treatment with UK and taurine , P < 0.05).
The ratio of cross area of vascular … lower after treatment with combination of UK … taurine than treatment with UK alone (0.4650 +/- 0.0928 vs 0.6176 +/- 0.1179, P < 0.05), … taurine can decrease significantly serum ET levels, potentiate UK-induced vascular recanlization and reduce ischemia reperfusion injury.
Zhonghua nei ke za zhi  •  1996  |  View Paper
Posttreatment with taurine at 4 or 6 h, urokinase at 4 h or in combination at 4, 6, or 8 h significantly reduced infarct volume and improved neurobehavioral outcome.
Together, the present study suggests that administration of taurine after stroke is neuroprotective, seemingly because it reduces the reperfusion damage of urokinase , leading to widen the therapeutic window for the thrombolytic effect of urokinase to 8 h. Thrombolysis can also enhance the neuroprotective effect of taurine.
Translational Stroke Research  •  2010  |  View Paper