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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Taurine and Sirolimus

supplement:

Taurine

Research Papers that Mention the Interaction

Inhibition of mTOR by rapamycin significantly reduced the activity of system A (-17%), system L (-28%), and taurine (-40%) amino acid transporters.
American journal of physiology. Cell physiology  •  2009  |  View Paper
Furthermore, taurine supplementation inhibited 5'AMP-activated protein kinase (AMPK) and activated mammalian target of rapamycin (mTOR).
Indeed, induction of autophagy by rapamycin could suppress the inhibitory effect of taurine on OTA-promoted PCV2 replication.
Chemico-biological interactions  •  2018  |  View Paper
Alteration in astrocyte volume in the presence of sirolimus was accompanied by reduction of the following important cell osmolytes and amino acid metabolites: myo-inositol, -58 +/- 12% (mean +/- standard deviation, n = 5); taurine , -44 +/- 5%; glutamine, -13 +/- 2%; compared with control.
Chemical research in toxicology  •  1997  |  View Paper