Possible Interaction: Taurine and Hypochlorite

“One established antioxidant action of taurine is the detoxification of hypochlorous acid.”

“Alanine and taurine sharply potentiate antiaggregant effects of hypochlorite on platelets in platelet-rich plasma.”

“Additionally, TauCl, produced by the reaction of taurine with HOCl , inhibits the activation of NF-kappaB followed by the inhibition of the production of the pro-inflammatory mediators.”

“One possibility is that taurine reacts with hypochlorous acid , produced by the myeloperoxidase pathway, to produce the more stable but less toxic taurine chloramine (Tau-Cl).”

“These cytotoxicities were significantly inhibited by the scavenger of hypochlorous acid, taurine.”

“In vivo, the unrestrained oxidant activity of HOCL is opposed by taurine , which reacts spontaneously with HOCL to generate taurine chloramine, much more stable than HOCL.”

“While transformation by HOCl was completely inhibited by 10 mM taurine , the level of metabolism of ABZ by MPO was only reduced 56%.”

“GBM degradation by supernatants obtained from incubations with catalase, azide, an inhibitor of myeloperoxidase, and methionine and taurine , scavengers of hypochlorous acid , was markedly reduced.”

“… taurine [1% or 4% (wt/vol) in drinking … rapidly with MPO-generated oxidants like hypochlorous acid , also prevented AAA formation in the ANG II and elastase models as well as the CaCl2 application … aortic peroxidase activity and aortic protein-bound dityrosine levels, an oxidative cross link formed by MPO.”

“ Taurine is an abundant amino acid in mammalian tissues including inflammatory cells where it acts as a trap for toxic hypochlorous acid (HOCl/OCl).”