Possible Interaction: Taurine and Doxorubicin Hydrochloride

“DOX efflux is inhibited by beta-alanine as a taurine transporter inhibitor, therefore, enhancement of the DOX level by taurine was suggested to act via taurine transport.”

“ Taurine did not change the DOX influx into M5076 cells, whereas it significantly inhibited DOX efflux, which maintained the DOX level in tumor cells.”

“Interestingly, doxorubicin co-treatment with taurine inhibited apoptosis in B16F10 cells.”

“These results indicate that doxorubicin co-treatment with taurine attenuates doxorubicin-induced cytotoxicity and reduces ROS production in B16F10 cells.”

“Elevations in the serum activity levels of lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase by DOX were also dose-dependently attenuated by a concurrent treatment with taurine.”

“Furthermore, the formation of cleaved caspase-3 protein in the group given DOX with taurine was lower than that in the group treated with DOX alone.”

“Superoxide dismutase activity and reduced glutathione content in the liver were decreased following the administration of DOX, whereas these changes were suppressed when 10 mg/kg taurine was given in combination with DOX.”

“ Taurine attenuated the increased expression of mRNAs for Fas and Bax after DOX exposure.”

“ Taurine zinc significantly attenuated the reductions in blood pressure, left ventricular pressure and ± dp/dtmax, increases in serum alanine aminotransferase and aspartate aminotransferase activities, and reductions in serum Zn(2+) and albumin levels (P<0.05 or 0.01) induced by doxorubicin.”

“In conclusion, taurine suppresses ROS generation and regulates gene expression in the DOX treated heart.”

“Oral administration of taurine (3% w/v in tap water) dramatically reduced the mortality rate in both the acute or sub-acute toxic models of DOX toxicity.”

“ Tau intervention could alleviate the increase of left ventricular diastolic pressure, Myo[Ca2+]i and the decrease of SERCA2a mRNA induced by doxorubicin.”

“Treatment of rats with taurine for 7 days before adriamycin , and daily thereafter, significantly lowered plasma cholesterol, triglycerides, phospholipids, lipid peroxides, and malondialdehyde associated with lipoprotein fractions.”

“The present study confirms our previous in vivo observations that taurine partially prevents doxorubicin-induced cardiotoxicity.”

“ Taurine significantly improved the survival rate of the mice treated with doxorubicin.”

“These results demonstrate that taurine antagonized doxorubicin-induced cardiotoxicity.”

“In strain TA98, doxorubicin mutagenicity , but not that of 2-aminofluorene or benzo(a)pyrene, was inhibited by taurine.”

“ Taurine inhibited mutagenesis by doxorubicin (-74%), bleomycin (-55%), mitomycin C (-56%), and 2-aminofluorene (-52%), but not danthrone or benzo(a)pyrene, in strain TA102.”

“ Taurine was more effective in inhibiting doxorubicin mutagenicity in strain TA102 than its analogues hypotaurine, beta-alanine, and guanidinoethanesulfonic acid or alanine or glycine.”