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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Taurine
drug:
Cholic Acid
Research Papers that Mention the Interaction
“It has been found that the processes of conjugation of cholic acid with glycine and taurine are inhibited in alloxan diabetes.”
[Correlations of bile acids in the bile of rats in conditions of alloxan induced diabetes melitus].“Thus, the inhibitory potential of bile acids towards microsomal enzymes was inversely related to their extent of hydroxylation, while taurine conjugation enhanced the inhibitory potential of cholic acid.”
“Thus, in the absence of Trophamine infusion, the percentage of cholic acid conjugated with taurine (ie, taurocholate) declined throughout the course of the cholic acid infusion.”
“Both treatments (TUDCA alone or TUDCA + taurine ) decreased the percentage of cholic acid without affecting 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase or cholesterol 7 alpha-hydroxylase activities.”
“Conjugation with taurine decreased the Km of CA but not the Vmax, while glycine conjugation did not alter either parameter, suggesting that conjugation with taurine may increase its affinity for the transport system.”
“it increases the intensity of the bile secretion, inhibits the synthesis of primary bile acids and conjugation of cholic acid with taurine and glycine, stimulates the formation, conjugation and secretion of bilirubin.”
“Inhibition of cholate synthesis might be accounted for by repressed production of deoxycholic and cholic acid from cholesterol as well as by repressed conjugation of cholic acid with taurine and glycine.”
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