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“The primary dihydroxy bile acid, chenodeoxycholate , was more toxic at high concentrations than at low concentrations, but conjugation with taurine reversed it.”
Advances in experimental medicine and biology • 1987 | View Paper
“ Taurine conjugates of chenodeoxycholate and deoxycholate, but not cholate and ursodeoxycholate, inhibited the CYP7A promoter/luciferase reporter activity in transient transfection assays in Hep G2 cells.”
Biological & pharmaceutical bulletin • 1993 | View Paper
“Conjugation of either lithocholate or chenodeoxycholate with either glycine or taurine markedly reduced the ability of the bile salt to enhance O2- release from primed PMNs.”
“The concentration of taurine conjugates of cholic acid … of both groups was similar, but concentration of taurine conjugates … chenodeoxycholic acid in bile of low responding animals was higher than in high responding animals (124.9 +/- ….3 in low vs. 59.2 +/- 13.2 &mgr;mol/ml in high responders).”