Possible Interaction: Taurine and Calcium Supplement

“ Taurine can prevent the Ca2+ ([Ca]o or [Ca]i)-induced cardiac functions.”

“ Taurine given in a similar manner for 4 months had a protective effect, decreasing lesion severity by 21% and calcium concentration by 35%.”

“The results showed that taurine attenuated the PCM-induced osteoblastic differentiation of AVICs by decreasing the alkaline phosphate (ALP) activity/… the core binding factor α1 (Cbfα1) in a dose-dependent manner (reaching the maximum protective effect at 10 mM), and taurine (10 mM) inhibited the … the form of calcium ….”

“Decreasing effects of taurine on Na−K ATPase activity or on calcium accumulation by lymphocytes might be responsible for its action on cell proliferation.”

“The mobility of the membranes decreased following treatment with 10 mM taurine , but coadministration of 2.5 mM calcium blocked this effect.”

“These actions of taurine and calcium on the dynamics of biological membranes might explain, in part, the observation that most of the pharmacological effects of taurine on mammalian organs occur in the presence of calcium ions.”

“Treatment of the membrane vesicles with calcium markedly inhibited taurine uptake.”

“ Ca , Mg-ATPase activity is significantly increased upon addition of 25 mM of taurine to the incubation medium.”

“The enzyme activity was not activated by taurine in the absence of calcium, but was significantly activated by taurine (15-60 mM) in the presence of calcium (5 mM) by which the enzyme is inhibited.”

“ Taurine also reduced ROS, intracellular Ca 2 + overload and mitochondrial membrane potential.”

“Therefore, we believe that taurine prevents ISO-induced H9c2 cardiomyocyte hypertrophy by inhibiting oxidative stress, intracellular Ca 2 + overload, the calpain-1-mediated mitochondria-dependent apoptotic pathway and cleaved caspase-9 levels.”

“Moreover, prolonged taurine treatment also increased the neural electrical activity by escalating changes of intracellular calcium concentration, the number of spontaneous Ca2+ oscillations in cells, and the frequencies of Ca2+ spikes.”