Possible Interaction: Taurine and Bismuth Subsalicylate

“ Taurine also modulates ER stress , Ca2+ homeostasis and neuronal activity at the molecular level as part of its broader roles.”

“The role of communication between the ER and mitochondrion is also important and examples are presented of protection by taurine against ER stress together with prevention of subsequent mitochondrial initiated apoptosis.”

“Finally, taurine suppressed both the changes of the important upstream regulators (calpain-1 and calpain-2) and the activation of ER stress , autophagy and apoptosis, and taurine had protective effects on the survival of ARPE-19 cells.”

“ Taurine has been known to protect the cells against ER stress.”

“The trauma of surgical stress was shown to dramatically increase the discharge frequency of RVLM neurons and promote the release of glutamate and taurine in the RVLM.”

“ Taurine , a major intracellular free amino acid, has been shown to inhibit ER stress and neuronal apoptosis in several neurological disorders.”

“The results demonstrated that taurine significantly reduced arsenite-induced ER stress in N2a cells.”

“Moreover, taurine can down-regulate the ratio of cleaved ATF6 and full length ATF6, and p-IRE1 expression, indicating that taurine inhibits the ER stress induced by hypoxia/reoxygenation and glutamate through suppressing ATF6 and IRE1 pathways.”

“We report that taurine significantly mitigated palmitate-mediated caspase-3 activity, cell death, ER stress , and oxidative stress in H4IIE liver cells and primary hepatocytes.”

“ ER stress is suppressed by taurine after glutamate toxicity.”