Possible Interaction: Taurine and Aspartate

“When the intracellular concentrations of aspartate and taurine were increased by pre-incubation, velocities of efflux increased linearly.”

“Metabolomic pathway analysis demonstrated that alanine, aspartate and glutamate metabolism, citrate cycle (TCA cycle), taurine and hypotaurine metabolism were significantly altered in MA.”

“The extracellular contents of glutamate and aspartate were increased, respectively, eight- and threefold during the ischemic period; the taurine concentration also was increased 2.6-fold.”

“Interestingly, heteroexchange only occurs in one preferred substrate orientation, i.e. with taurine transported inwards and aspartate outwards, suggesting a mechanism of transinhibition of aspartate uptake by intracellular taurine.”

“The addition of taurine to the perfusion medium significantly reduced the depolarization-evoked increases in Glu, Asp , and GABA release.”

“The excitatory amino acids homocysteate, aspartate and kainate enhanced taurine release particularly from the developing cerebral cortex but were not effective on GABA release in the adults.”

“ Aspartate (10 mM), which is known to eliminate the light response of cells postsynaptic to photoreceptors, induced a marked increase of 150% in the resting efflux of 3H‐taurine but did not decrease significantly the light‐stimulated release.”

“The extracellular contents of glutamate and aspartate were increased, respectively, eight‐and threefold during the ischemic period; the taurine concentration also was increased 2.6‐fold.”

“The depolarizations by 3-types of excitatory amino acids were also inhibited by taurine in the following order: N-methyl-D, L-aspartate greater than kainate greater than quisqualate.”