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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Tannins and Doxorubicin Hydrochloride

Research Papers that Mention the Interaction

Further, it reduces the cell viability of MDA-MB-231 breast cancer cells, increases p53 expression in mammary tumors and shows maximum tumor volume reduction, suggesting that tannic acid potentiates the anti-cancer activity of doxorubicin.
Toxicology and applied pharmacology  •  2011  |  View Paper
Resveratrol, epigallocatechin gallate, and tannic acid are polyphenolic compounds that were reported to have cardioprotective effect when combined with doxorubicin.
The combined use of epigallocatechin gallate or tannic acid with doxorubicin at a certain concentration could mitigate doxorubicin-induced keratinocyte cytotoxicity without weakening doxorubicin anticancer efficacy.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology  •  2018  |  View Paper
TA significantlyattenuated DOX myocardial effects.
…,DOX provoked inflammatory responses by causing anincrease in levels of pro-inflammatory … levels, and nuclear factor kappa-B (NF-κB) expression while TA pretreatment significantly inhibited TNF-α, IL-1β, ET-1, and NF-κB. Furthermore, … c-jun levels while causing a decrease in B-cell lymphoma-2 levels.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2017  |  View Paper
The TA interaction with DOX via electrostatic interaction, hydrogen bonding and hydrophobic interaction showed a sustained drug release profile.
Cancers  •  2020  |  View Paper