Possible Interaction: Tannins and Cupric Cation

“It is shown that tannic acid is the most efficient generator of the hydroxyl radical in the presence of Cu(II) , as compared with gallic acid and its analogues syringic acid and pyrogallol.”

“We have previously shown that tannic acid in the presence of Cu(II) causes DNA degradation through generation of reactive oxygen species.”

“We have earlier shown that tannic acid in the presence of Cu(II) causes DNA degradation through generation of reactive oxygen species such as hydroxyl radicals.”

“In the ternary Cu-TA-nHAP systems, TA promoted Cu(II) adsorption at pH < 5 and reduced Cu(II) uptake at pH > 5.”

“Changes of resin's Zeta potential and acids' average molecular size were observed when Cu(II) was added in solutions, which could explain the significant increase in WJN-09's adsorption capacity for tannic and gallic acids in the presence of Cu(II).”

“In this work, we observed that TA inhibits, in the micromolar range, in vitro Cu(II) plus ascorbate-mediated hydroxyl radical (*OH) formation (determined as 2-deoxyribose degradation) and oxygen uptake, as well as copper-mediated ascorbate oxidation and ascorbate radical formation (quantified in EPR studies).”

“Moreover, the inhibitory effectiveness of TA , by the four techniques used herein, was inversely proportional to the Cu(II) concentration in the media.”