Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Tamoxifen and Vitamin E


Vitamin E

Research Papers that Mention the Interaction

Tamoxifen elevated lipid peroxidation and the release of cytochrome c, and these effects of tamoxifen were reduced by α-tocopherol.
The inhibition of the growth of pancreatic cancer cells induced by tamoxifen was effectively reduced by α-tocopherol , a membrane stabilizer.
International journal of oncology  •  2015  |  View Paper
Various antioxidants vitamin E , vitamin C, β-carotene, catalase, and superoxide dismutase) inhibited all these cellular effects of Tam.
The Journal of Biological Chemistry  •  1996  |  View Paper
alpha-Tocopherol (32 microM) almost completely prevented cell death due to either CsA or tamoxifen.
Xenobiotica; the fate of foreign compounds in biological systems  •  1995  |  View Paper
BACKGROUND Vitamin E (alpha-tocopherol acetate, AT) diminishes the antiproliferative effect of tamoxifen on breast cancer cells in vitro.
Findings suggest that vitamin E supplements may interfere with the therapeutic effects of tamoxifen.
The Journal of surgical research  •  2009  |  View Paper
CONCLUSIONS These studies suggest that supplemental vi amin E de creases the inhibitory effect of TAM on the proliferation of ER+ breast cancer cells and eliminates the rapid rise in intracellular calcium that leads to apoptosis stimulated by TAM.
Our hypothesis that supplemental antioxidant vitamin E (alpha-tocopherol) acts at the plasma membrane to alter the effectiveness of tamoxifen was tested in ER-positive breast cancer cell lines, MCF-7 and T47D.
The addition of AT led to the restoration of cell proliferation and p-ERK expression even in the presence of high-dose TAM.
The use of vitamin E acetate supplements may be inadvisable for women taking tamoxifen.
Surgery  •  2006  |  View Paper
Vitamin E altered and decreased the growth inhibition induced by tamoxifen (10 μM) in MCF-7 (33%) and T47D (54%) cells.
Nutrition and cancer  •  2005  |  View Paper
α-tocopherol (vitamin E) diminished the effects of tamoxifen on PKC-acivity as well as on telomerase activity.
Journal of Cancer Research and Clinical Oncology  •  2004  |  View Paper
Either alpha-T or alpha-TAc increases membrane packing and prevents TAM partition into model membranes.
The hemolytic effect of TAM is prevented by low concentrations of alpha-tocopherol (alpha-T) and alpha-tocopherol acetate (alpha-TAc) (inactivated functional hydroxyl) indicating that TAM-induced hemolysis is not related to oxidative membrane damage.
Biochimica et biophysica acta  •  2000  |  View Paper
Vitamin E (800 IU per day) was found to have a modest effect on hot flashes during tamoxifen treatment.
Breast Care  •  2010  |  View Paper