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The Journal of surgical research • 2009 | View Paper
“CONCLUSIONS These studies suggest that supplemental vi amin E de creases the inhibitory effect of TAM on the proliferation of ER+ breast cancer cells and eliminates the rapid rise in intracellular calcium that leads to apoptosis stimulated by TAM.”
“Our hypothesis that supplemental antioxidant vitamin E (alpha-tocopherol) acts at the plasma membrane to alter the effectiveness of tamoxifen was tested in ER-positive breast cancer cell lines, MCF-7 and T47D.”
“The addition of AT led to the restoration of cell proliferation and p-ERK expression even in the presence of high-dose TAM.”
“The use of vitamin E acetate supplements may be inadvisable for women taking tamoxifen.”
Journal of Cancer Research and Clinical Oncology • 2004 | View Paper
“Either alpha-T or alpha-TAc increases membrane packing and prevents TAM partition into model membranes.”
“The hemolytic effect of TAM is prevented by low concentrations of alpha-tocopherol (alpha-T) and alpha-tocopherol acetate (alpha-TAc) (inactivated functional hydroxyl) indicating that TAM-induced hemolysis is not related to oxidative membrane damage.”