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Last Updated: 2 months ago

Possible Interaction: Tamoxifen and Vitamin D

supplement:

Vitamin D

Research Papers that Mention the Interaction

We found that one week or 2 weeks pretreatment of prepubertal rats with vitamin D analogs led to increased induction of CK by E(2) and by the SERMS tamoxifen , tamoxifen methiodide and raloxifene, in epiphysis and diaphysis of the femur but not in the uterus.
The Journal of Steroid Biochemistry and Molecular Biology  •  2000  |  View Paper
Vitamin D3 was not associated to CYP3A4 metabolic activity, indicating that other mechanisms might be involved in the relation between TAM metabolism and vitamin D exposure.
Therapeutic drug monitoring  •  2015  |  View Paper
The growth inhibitory effect on the 2 cell lines could be augmented and accompanied by a decrease in EGFR mRNA level after combined treatment with IC50 dose of tamoxifen and 10(-10)-10(-9) mol/L vitamin D3.
Zhonghua zhong liu za zhi [Chinese journal of oncology]  •  2000  |  View Paper
TAM (100 microM) also completely blocked prostaglandin E2 (30 nM)- and 1,25-dihydroxy vitamin D3 (0.5 nM)-induced bone resorption.
Endocrinology  •  1986  |  View Paper
This observation could partially explain the potentiation of the antiproliferative effect of tamoxifen by vitamin D analogs.
Cancers  •  2013  |  View Paper