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Last Updated: 2 months ago

Possible Interaction: Tamoxifen and Vitamin C

supplement:

Vitamin C

Research Papers that Mention the Interaction

Various antioxidants (vitamin E, vitamin C , β-carotene, catalase, and superoxide dismutase) inhibited all these cellular effects of Tam.
The Journal of Biological Chemistry  •  1996  |  View Paper
Pre‐treatment with vitamin C caused a dose‐dependent attenuation of cytotoxicity, as measured by acridine‐orange/propidium iodide (AO/PI) and Annexin V assay after treatment with TAM.
Vitamin C dose‐dependently protected cancer cells against lipid peroxidation caused by TAM treatment.
Journal of cellular and molecular medicine  •  2014  |  View Paper
Conclusion: The results compared vitamin C-treated breast cancer patients with normal individuals and showed that co-administration of vitamin C is more beneficial in breast cancer patients treated with tamoxifen.
Chemotherapy  •  2010  |  View Paper
The concurrent exposure of the explants to 100 micro M tamoxifen with 1mM ascorbic acid reduced the level of alpha-hydroxytamoxifen substantially (68.9%).
Biochemical and biophysical research communications  •  2003  |  View Paper
17beta-estradiol, synthetic estrogen diethylstilbestrol, and partial agonist tamoxifen were found to inhibit ascorbic acid accumulation in a dose-dependent fashion.
European journal of pharmacology  •  1998  |  View Paper
The administration of riboflavin (45 mg/kg … (100 mg/kg bw/day) and ascorbic acid (200 mg/…) along with tamoxifen (45 mg/kg bw/day) caused a significant decrease in the activity of glycolytic enzymes … increase in the activities of gluconeogenic enzymes to near normal levels in experimental animals.
Molecular and Cellular Biochemistry  •  2006  |  View Paper
E(2) significantly elevated both AA and LHRH release and the minimal effective dose was 10(-7) M. A combination of E(2) (10(-7) M) and tamoxifen (10(-6) M) totally blocked E(2)-induced AA and LHRH release.
Experimental biology and medicine  •  2004  |  View Paper
Additionally, ascorbic acid and glutathione, inhibitors of covalent binding of tamoxifen , produced an elevation of methylated catechol.
Cancer research  •  1996  |  View Paper