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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Tamoxifen and Tyrosine



Research Papers that Mention the Interaction

In part, this derived from TAM downregulating manganese superoxide dismutase (MnSOD) activity by causing the nitrosylation of tyrosine 34 , thereby increasing ROS.
Oncogene  •  2013  |  View Paper
Tamoxifen also induced an association between c-Src and PKCdelta that resulted in the tyrosine phosphorylation and down-regulation of PKCdelta.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research  •  2001  |  View Paper
Pretreatment of two cell lines with tamoxifen resulted in a dose dependent inhibition of tyrosine phosphorylation as well as DNA synthesis and cell growth in two cell lines correlatively.
The Kobe journal of medical sciences  •  2001  |  View Paper
Pretreatment of the cells with PKC inhibitors, CGP 41251 or tamoxifen , inhibited tyrosine phosphorylation of Erk1 and Erk2 MAP kinases induced by low concentrations of SP or TPA and significantly attenuated phosphorylation at high concentrations of SP or TPA.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research  •  1997  |  View Paper
In MCF-7 and MCF-7/IGF-IR cells, growth inhibition by Tam was associated with the reduced tyrosine phosphorylation of the IGF-IR in the presence of IGF-I; however, the basal level of the IGF-IR remained unaffected.
Cancer research  •  1997  |  View Paper
Furthermore, the decrease in IGFBPs and the increase in tyrosine phosphorylation in the presence of tamoxifen provides a molecular mechanism that accounts for the uterotropic effects that are seen with tamoxifen therapy.
Endocrinology  •  1996  |  View Paper