Possible Interaction: Tamoxifen and Tangeretin

“Experiments with nude mice bearing MCF-7/6 tumors showed that tangeretin given orally at high doses, abrogated the therapeutic suppression of tumor growth exerted by tamoxifen.”

“The second effect can become important when high doses of tangeretin are combined with adjuvant tamoxifen treatment for breast cancer.”

“BACKGROUND Tamoxifen and the citrus flavonoid tangeretin exhibit similar inhibitory effects on the growth and invasive properties of human mammary cancer cells in vitro; furthermore, the two agents have displayed additive effects in vitro.”

“In our study, the tumor growth-inhibiting effect of oral tamoxifen was reversed upon addition of tangeretin to the diet.”

“In this study, we examined whether tangeretin would enhance tamoxifen's therapeutic benefit in vivo.”

“The median survival time of tumor-bearing mice treated with tamoxifen plus tangeretin was reduced in comparison with that of mice treated with tamoxifen alone (14 versus 56 weeks; two-sided P = .002).”