Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Tamoxifen and Soy Isoflavones

supplement:

Soy Isoflavones

Research Papers that Mention the Interaction

More concerning is the concurrent consumption of soy isoflavones with tamoxifen (TAM) for prevention or treatment of breast cancer.
Nutrition and cancer  •  2007  |  View Paper
The possibility that soy isoflavones could reduce tamoxifen efficacy has been demonstrated in animal models of post-menopausal breast cancer, but the occurrence of such an effect in women has not been explored.
Journal of AOAC International  •  2006  |  View Paper
Women commonly experience weight gain after diagnosis and soy isoflavones may interfere with effect of tamoxifen.
The Journal of the Oklahoma State Medical Association  •  2008  |  View Paper
The soy isoflavone genistein increased growth of human breast tumor xenografts in mice and reduced the effects of tamoxifen against these tumors.
Cancer investigation  •  2003  |  View Paper