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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Tamoxifen
supplement:
Soy Isoflavones
Research Papers that Mention the Interaction
“More concerning is the concurrent consumption of soy isoflavones with tamoxifen (TAM) for prevention or treatment of breast cancer.”
The Effect of the Phytoestrogens Genistein, Daidzein, and Equol on the Growth of Tamoxifen-Resistant T47D/PKCα“The possibility that soy isoflavones could reduce tamoxifen efficacy has been demonstrated in animal models of post-menopausal breast cancer, but the occurrence of such an effect in women has not been explored.”
“Women commonly experience weight gain after diagnosis and soy isoflavones may interfere with effect of tamoxifen.”
“The soy isoflavone genistein increased growth of human breast tumor xenografts in mice and reduced the effects of tamoxifen against these tumors.”
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