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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Tamoxifen and Soy Isoflavones


Soy Isoflavones

Research Papers that Mention the Interaction

More concerning is the concurrent consumption of soy isoflavones with tamoxifen (TAM) for prevention or treatment of breast cancer.
Nutrition and cancer  •  2007  |  View Paper
The possibility that soy isoflavones could reduce tamoxifen efficacy has been demonstrated in animal models of post-menopausal breast cancer, but the occurrence of such an effect in women has not been explored.
Journal of AOAC International  •  2006  |  View Paper
Women commonly experience weight gain after diagnosis and soy isoflavones may interfere with effect of tamoxifen.
The Journal of the Oklahoma State Medical Association  •  2008  |  View Paper
The soy isoflavone genistein increased growth of human breast tumor xenografts in mice and reduced the effects of tamoxifen against these tumors.
Cancer investigation  •  2003  |  View Paper