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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Tamoxifen and Serum Albumin, Human

Research Papers that Mention the Interaction

HSA conformation was altered by tamoxifen and its metabolites with a major reduction of α-helix and an increase in β-sheet, random coil and turn structures, indicating a partial protein unfolding.
Biochimie  •  2011  |  View Paper
Furthermore, the results of synchronous fluorescence, resonance light scattering and circular dichroism of the binary and ternary systems showed that the binding of TMX and ASA to HSA could induce conformational changes in HSA.
Moreover, the simultaneous presence of TMX and ASA during binding to HSA should be taken into account in multi-drug therapy, as it induces the necessity of a monitoring therapy owing to the possible increase of uncontrolled toxic effects.
Protein and peptide letters  •  2011  |  View Paper
Tamoxifen was also extensively bound (> 99%) to HSA.
The percent free tamoxifen increased upon HSA dilution.
The Journal of pharmacy and pharmacology  •  1991  |  View Paper