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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Tamoxifen
supplement:
Serum Albumin, Human
Research Papers that Mention the Interaction
“ HSA conformation was altered by tamoxifen and its metabolites with a major reduction of α-helix and an increase in β-sheet, random coil and turn structures, indicating a partial protein unfolding.”
Binding of antitumor tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen to human serum albumin.“Furthermore, the results of synchronous fluorescence, resonance light scattering and circular dichroism of the binary and ternary systems showed that the binding of TMX and ASA to HSA could induce conformational changes in HSA.”
“Moreover, the simultaneous presence of TMX and ASA during binding to HSA should be taken into account in multi-drug therapy, as it induces the necessity of a monitoring therapy owing to the possible increase of uncontrolled toxic effects.”
“ Tamoxifen was also extensively bound (> 99%) to HSA.”
“The percent free tamoxifen increased upon HSA dilution.”
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