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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Tamoxifen
supplement:
Resveratrol
Research Papers that Mention the Interaction
“In addition, the estrogen antagonists tamoxifen and ICI 182,780 inhibited the induction by resveratrol , and resveratrol was unable to activate the reporter system in an ER-negative breast cancer cell line (MDA-MB-231), unless ERs were cotransfected.”
Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'?“In parallel, we demonstrated that resveratrol was capable of synergizing with tamoxifen and triggering apoptosis in MCF-7/TR cells.”
“Cell growth stimulated by RSV (10(-6) M) was blocked by addition of a blocking IGF-I receptor antibody, or the antiestrogen tamoxifen (10(-7) M).”
“Moreover, the antiestrogen tamoxifen eliminated the stimulation of MC3T3-E1 cells on the proliferation and ALP activity by resveratrol.”
Resveratrol stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells.
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