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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Tamoxifen
supplement:
Phosphatidylethanolamine
Research Papers that Mention the Interaction
“In an estrogen receptor‐deficient multidrug‐resistant subline of MCF‐7 cells, TAM preferentially stimulated the hydrolysis of phosphatidylethanolamine ; two‐fold stimulation required 2.5 or 5 μM TAM in the absence or presence of serum, respectively.”
Tamoxifen stimulates phospholipase D activity by an estrogen receptor‐independent mechanism“ Tamoxifen (20 microM in artificial cerebrospinal fluid), applied topically, inhibited the ischemia-evoked efflux of aspartate, glutamate, taurine and phosphoethanolamine.”
Tamoxifen, a chloride channel blocker, reduces glutamate and aspartate release from the ischemic cerebral cortex“Treatment with tamoxifen led to a significant reduction in the PE to PE+PC peak amplitude ratio in the tumors under consideration.”
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