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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Tamoxifen
supplement:
Kaempferol
Research Papers that Mention the Interaction
“This study demonstrated that luteolin inhibits the proliferation and induces apoptosis of tamoxifen-resistant ER-positive breast cancer cells.”
MLL3 Induced by Luteolin Causes Apoptosis in Tamoxifen-Resistant Breast Cancer Cells through H3K4 Monomethylation and Suppression of the PI3K/AKT/mTOR Pathway.“Hence, it could be expected that kaempferol would affect the pharmacokinetics of tamoxifen.”
“In the presence of kaempferol , the total area under the plasma concentration-time curve from time zero to time infinity (AUC) of tamoxifen was significantly greater, C(max) was significantly higher and F was considerably greater than those without kaempferol.”
Effects of oral kaempferol on the pharmacokinetics of tamoxifen and one of its metabolites, 4-hydroxytamoxifen, after oral administration of tamoxifen to rats.“The effect of luteolin in increasing collagen content and ALP activity was completely prevented by the presence of 10−6M cycloheximide and 10−6M tamoxifen , suggesting that luteolin's effect results from a newly synthesized protein component and might be partly involved in estrogen action.”
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