Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Tamoxifen and Kaempferol

supplement:

Kaempferol

Research Papers that Mention the Interaction

Hence, it could be expected that kaempferol would affect the pharmacokinetics of tamoxifen.
In the presence of kaempferol , the total area under the plasma concentration-time curve from time zero to time infinity (AUC) of tamoxifen was significantly greater, C(max) was significantly higher and F was considerably greater than those without kaempferol.
Biopharmaceutics & drug disposition  •  2008  |  View Paper
The effect of luteolin in increasing collagen content and ALP activity was completely prevented by the presence of 10−6M cycloheximide and 10−6M tamoxifen , suggesting that luteolin's effect results from a newly synthesized protein component and might be partly involved in estrogen action.
Cell biology international  •  2007  |  View Paper
This study demonstrated that luteolin inhibits the proliferation and induces apoptosis of tamoxifen-resistant ER-positive breast cancer cells.
The American journal of Chinese medicine  •  2020  |  View Paper