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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Tamoxifen and Indole-3-Carbinol

Research Papers that Mention the Interaction

A combination of I3C and tamoxifen also caused a more pronounced decrease in cyclin-dependent kinase (CDK) 2-specific enzymatic activity than either compound alone but had no effect on CDK2 protein expression.
These results demonstrate that I3C and tamoxifen work through different signal transduction pathways to suppress the growth of human breast cancer cells and may, therefore, represent a potential combinatorial therapy for estrogen-responsive breast cancer.
Cancer research  •  1999  |  View Paper
The antiestrogen tamoxifen also suppressed MCF7 cell DNA synthesis but had no effect on CDK6 expression, while a combination of I3C and tamoxifen inhibited MCF7 cell growth more stringently than either agent alone.
The Journal of Biological Chemistry  •  1998  |  View Paper
Since N-desmethyl-TAM is transformed to a genotoxic metabolite, dietary exposure to I3C may enhance hepatic carcinogenicity of TAM in the rat.
Cancer detection and prevention  •  2004  |  View Paper