Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Tamoxifen and Ginseng

supplement:

Ginseng

Research Papers that Mention the Interaction

Results: Four of the herbals tested, echinacea, ginseng , lemon balm, and skullcap, were found to be strong inhibitors of the CYP450 enzymatic bioactivation pathways of TAM with IC50 values as percent of a single dose ranging from 0.019% to 0.34%.
Drug metabolism and drug interactions  •  2014  |  View Paper
In another paper titled “The Prescription Pattern of Chinese Herbal Products Containing Ginseng among Tamoxifen-Treated Female Breast Cancer Survivors in Taiwan: A Population-Based Study,” W.-L. Hsu et al. investigate the inhibitory relationship between Ginseng consumption and subsequent endometrial cancer among tamoxifen users.
Three papers are related to breast cancer risk of commonly used Chinese herbs; one of them considers the breast cancer risk of Chinese herbal remedies among hormone users, while another covers the subsequent endometrial cancer problems when tamoxifen users consume Ginseng.
Evidence-based complementary and alternative medicine : eCAM  •  2015  |  View Paper
A significant inhibitory relationship between Ginseng consumption and subsequent endometrial cancer less than 2 years after TMX treatment was detected among BC survivors.
Evidence-based complementary and alternative medicine : eCAM  •  2015  |  View Paper