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Last Updated: 2 months ago

Possible Interaction: Tamoxifen and Genistein

supplement:

Genistein

Research Papers that Mention the Interaction

Genistein also shows synergistic behavior with well-known anticancer drugs, such as adriamycin, docetaxel, and tamoxifen , suggesting a potential role in combination therapy.
Advances in nutrition  •  2015  |  View Paper
GE treatment also re-sensitized ERα-dependent cellular responses to activator 17β-estradiol (E2) and antagonist TAM.
The soybean isoflavone, genistein (GE), has been shown to prevent and inhibit breast cancer and recent studies have suggested that GE can enhance the anticancer capacity of an estrogen antagonist, tamoxifen (TAM), especially in ERα-positive breast cancer cells.
Molecular Cancer  •  2012  |  View Paper
We have demonstrated that dietary GEN can negate the inhibitory effect of tamoxifen.
Carcinogenesis  •  2008  |  View Paper
In addition, genistein and TAM combination synergistically delayed the growth of breast tumor via decreased estrogen level and activity, and down-regulation of EGFR expression.
The combination of TAM with genistein or SPC, especially at the lower dose of TAM, had synergistic effects on delaying the growth of MCF-7 tumors.
Carcinogenesis  •  2007  |  View Paper
Interestingly, coadministration of TAM with either daidzein or genistein produced tumors of greater size than with TAM alone.
Nutrition and cancer  •  2007  |  View Paper
In vitro studies of human and mouse mammary tumor cell lines confirm that low doses of genistein , co-administered with tamoxifen , promote cell proliferation.
Cancer research  •  2005  |  View Paper
Genistein acts synergistically with drugs such as tamoxifen , cisplatin, 1,3-bis 2-chloroethyl-1-nitrosourea (BCNU), dexamethasone, daunorubicin and tiazofurin, and with bioflavonoid food supplements such as quercetin, green-tea catechins and black-tea thearubigins.
Advances in experimental medicine and biology  •  2004  |  View Paper
We hypothesized that weakly estrogenic genistein negate/overwhelm the inhibitory effect of TAM on the growth of E-dependent breast tumors.
Cancer research  •  2002  |  View Paper
At high concentrations, genistein inhibited tumor growth and enhanced the effect of tamoxifen in vitro.
The Annals of pharmacotherapy  •  2001  |  View Paper
In micromolar concentrations (0.1-10 μM) genistein decreased the cytotoxic effects of cisplatin and tamoxifen.
It is shown that the half maximal inhibitory concentration (IC50) value of genistein (0.2 mM) for the growth inhibition of HeLa cells is at least ten times higher than that one of tamoxifen and cisplatin--drugs, used in cervical cancer treatment.
Biofizika  •  2015  |  View Paper
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