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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Tamoxifen and Gamma-Linolenic Acid

Research Papers that Mention the Interaction

The effects of GLA on ER function and the possibility of synergistic inhibitory action of GLA with tamoxifen via enhanced down‐regulation of the ER pathway require further investigation.
International journal of cancer  •  2001  |  View Paper
Gamma linolenic acid (GLA) has been shown to decrease the invasion of breast cancer and recent studies have demonstrated that GLA can enhance the oestrogen receptor down-regulation induced by tamoxifen.
International journal of pharmaceutics  •  2004  |  View Paper
The 1H NMR data supported the hypothesis that such complexation was a consequence of preferential pi-pi orbital interactions between the phenyl groups of tamoxifen and the multiple double bonds of GLA.
International journal of pharmaceutics  •  2005  |  View Paper