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Last Updated: 2 months ago

Possible Interaction: Tamoxifen and Epigallocatechin Gallate

Research Papers that Mention the Interaction

Furthermore, EGCG enhances the efficacy of anti-glioma therapies, including irradiation, temozolomide, carmustine, cisplatin, tamoxifen , and TNF-related apoptosis-inducing ligand, but reduces the effect of bortezomib.
Nutrition and cancer  •  2018  |  View Paper
Experimental trials suggest a synergistic interaction of green tea catechins with tamoxifen or raloxifene in the treatment of estrogen receptor-positive and estrogen receptor-negative breast cancer through estrogen receptor-dependent and -independent mechanisms.
Pharmacology  •  2014  |  View Paper
The results demonstrate that tamoxifen at realistic doses (75 μg kg−1) can suppress the growth of ER-negative breast cancer when combined with EGCG.
British Journal of Cancer  •  2008  |  View Paper
Furthermore, in vitro studies have demonstrated that the combination of EGCG and tamoxifen is synergistically cytotoxic to ERalpha- breast cancer cells.
IDrugs : the investigational drugs journal  •  2003  |  View Paper
We recently found synergistic effects of EGCG and cancer preventive agents such as tamoxifen and sulindac, on cancer preventive activity.
BioFactors  •  2000  |  View Paper
In protein expression of Bax/Bcl-2, EGCG significantly increased 6-fold while this ratio augmented 10-fold in tamoxifen group.
Pharmacological reports : PR  •  2017  |  View Paper
In conclusion, the present results showed that EGCG could down-regulate the activity of two molecules that play a key role in drug metabolism and transport and that are highly expressed in tamoxifen resistant breast carcinoma cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology  •  2010  |  View Paper
Treatment with EGCG inhibited telomerase expression significantly (P < 0.01) and enhanced the effect of cisplatin and tamoxifen in both 1321N1 (P < 0.01) and U87-MG (P < 0.001) cells.
Molecular Biology Reports  •  2008  |  View Paper
Consequently, the … bioavailability of tamoxifen in the … of EGCG (3 and 10 mg/kg) was 48.9–78.1%, which was significantly enhanced (P<0.05 for 3 mg/kg of EGCG, P<0.01 for 10 mg/kg of EGCG) compared with the oral control group (23.7%).
The increase in oral bioavailability of tamoxifen in the presence of EGCG should be taken into consideration of potential drug interactions between tamoxifen and EGCG.
The presence of EGCG significantly altered the pharmacokinetics of orally administered tamoxifen.
Anti-cancer drugs  •  2009  |  View Paper
Looking at the concept of combination cancer chemoprevention, we previously reported the synergistic effects of (−)-epigallocatechin gallate (EGCG) with sulindac, and the additive effects of EGCG with tamoxifen , on cancer-preventive activity in human lung cancer cell line PC-9.
Journal of Cancer Research and Clinical Oncology  •  2001  |  View Paper
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