supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago
drug:
Tamoxifen
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“ Tamoxifen produced significant falls in serum alkaline phosphatase (P < 0.0001), ionized calcium (P < 0.0001), and phosphate (P < 0.01), and in urinary excretion of hydroxyproline, n-telopeptides, and calcium (P < 0.05 for each).”
The effect of the antiestrogen tamoxifen on bone mineral density in normal late postmenopausal women.“It was concluded that tamoxifen treatment mobilized calcium from the intra- or extra-cellular pools with a concomitant increase in cAMP and presumably activation of PKA (protein kinase A).”
“ Tamoxifen increased the intracellular calcium concentration of skin SCC cells, and this increase in intracellular calcium concentration by calcium ionophore A23187 suppressed the proliferation of skin SCC cells.”
“In transfected cells, 10 μmol/L tamoxifen reduced the basal intracellular calcium concentration to the basal calcium level of nontransfected cells.”
“ Tamoxifen decreased the transport rates of calcium and barium in transfected cells by 50%.”
“ Tamoxifen (10(-6) mol/L) also increased the releasing of calcium in Bcap-37 and HeLa cells.”
“These results demonstrate that the restoration of the E-cadherin function induced by tamoxifen depends, at least in part, on a Ca2+ pathway , and support the evidence of an effect of tamoxifen on Ca(2+)-dependent mechanisms.”
“Previously, we showed that treatment of laying female zebra finches (Taeniopygia guttata) with the antiestrogen tamoxifen can decrease egg size by ca.”
Experimental (Antiestrogen‐Mediated) Reduction in Egg Size Negatively Affects Offspring Growth and Survival“The antiestrogen Tamoxifen (60 mg/kg BW, given orally) reduced plasma Ca , but did not affect the synthesis of calbindin mRNA in the ESG.”
“Plasma calcium concentrations and oviduct weights were significantly decreased by tamoxifen at both dose levels and under both dietary conditions.”
“The supplementation of the growth medium with Ca2+ (a membrane stabilizer) partially relieves growth inhibition by TAM , allowing growth at TAM concentrations that fully impair growth in the basal medium.”
Lipid composition changes induced by tamoxifen in a bacterial model system.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback