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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Tamoxifen
supplement:
Biochanin A
Research Papers that Mention the Interaction
“As BCA is an inhibitor of CYP 3A and P‐gp it was expected to increase the bioavailability of tamoxifen , a known substrate of CYP3A4/Pgp.”
“Consequently, the relative bioavailability (RB%) of tamoxifen co‐administered with BCA was remarkably decreased compared with the control group.”
“If the results of this study are further confirmed by clinical trials, tamoxifen dosages should be adjusted to avoid potential drug interaction when tamoxifen is used clinically in combination with BCA and BCA‐containing dietary supplements.”
Reduced Bioavailability of Tamoxifen and its Metabolite 4‐Hydroxytamoxifen After Oral Administration with Biochanin A (an Isoflavone) in Rats“Hence, it could be expected that BCA would affect the pharmacokinetics of tamoxifen.”
“A combination of three (genistein, daidzein, and glycitein) to five isoflavones (plus biochanin A and formononetin) inhibited tamoxifen α-hydroxylation to a greater extent but did not decrease the formation of identified metabolites.”
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