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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Tamoxifen and Biochanin A

supplement:

Biochanin A

Research Papers that Mention the Interaction

As BCA is an inhibitor of CYP 3A and P‐gp it was expected to increase the bioavailability of tamoxifen , a known substrate of CYP3A4/Pgp.
Consequently, the relative bioavailability (RB%) of tamoxifen co‐administered with BCA was remarkably decreased compared with the control group.
If the results of this study are further confirmed by clinical trials, tamoxifen dosages should be adjusted to avoid potential drug interaction when tamoxifen is used clinically in combination with BCA and BCA‐containing dietary supplements.
Phytotherapy research : PTR  •  2012  |  View Paper
Hence, it could be expected that BCA would affect the pharmacokinetics of tamoxifen.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences  •  2011  |  View Paper
A combination of three (genistein, daidzein, and glycitein) to five isoflavones (plus biochanin A and formononetin) inhibited tamoxifen α-hydroxylation to a greater extent but did not decrease the formation of identified metabolites.
Pharmaceutical Research  •  2004  |  View Paper