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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Talinolol
supplement:
St John's Wort
Research Papers that Mention the Interaction
“Clinical trials indicate …’s wort Hypericum perforatum ), via cytochrome P450 (CYP) and/or P-glycoprotein induction, reduces the plasma concentrations (and/or increases the clearance) of alprazolam, …, ciclosporin, debrisoquine, digoxin, erythromycin, fexofenadine, gliclazide, imatinib, indinavir, irinotecan, ivabradine, mephenytoin, methadone, midazolam, nifedipine, omeprazole, oral contraceptives, quazepam, simvastatin, tacrolimus, talinolol , verapamil, ….”
Interactions Between Herbal Medicines and Prescribed Drugs“Long‐term SJW decreased talinolol AUC with a corresponding increase in intestinal MDR1 expression, suggesting that SJW has a major inductive effect on intestinal P‐glycoprotein.”
“ SJW reduced the oral talinolol bioavailability by 25% (P=0.049) compared with water control.”
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