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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Talinolol and St John's Wort

supplement:

St John's Wort

Research Papers that Mention the Interaction

Clinical trials indicate …’s wort Hypericum perforatum ), via cytochrome P450 (CYP) and/or P-glycoprotein induction, reduces the plasma concentrations (and/or increases the clearance) of alprazolam, …, ciclosporin, debrisoquine, digoxin, erythromycin, fexofenadine, gliclazide, imatinib, indinavir, irinotecan, ivabradine, mephenytoin, methadone, midazolam, nifedipine, omeprazole, oral contraceptives, quazepam, simvastatin, tacrolimus, talinolol , verapamil, ….
Drugs  •  2012  |  View Paper
Long‐term SJW decreased talinolol AUC with a corresponding increase in intestinal MDR1 expression, suggesting that SJW has a major inductive effect on intestinal P‐glycoprotein.
SJW reduced the oral talinolol bioavailability by 25% (P=0.049) compared with water control.
Clinical pharmacology and therapeutics  •  2007  |  View Paper