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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Talinolol
supplement:
Ginkgo Biloba Whole
Research Papers that Mention the Interaction
“Conclusions Our results suggest that long-term use of GBE significantly influenced talinolol disposition in humans, likely by affecting the activity of P-glycoprotein and/or other drug transporters.”
“… GBE … talinolol maximum plasma concentration (Cmax) by 36% (90% CI 10 to 68; p = 0.025), the area under the concentration-time curve (AUC)0-24 …-∞ by 22% (90% CI 8 to 37; p = 0.014), respectively, without significant changes in elimination half-life and the time to Cmax.”
Effects of Ginkgo biloba Extract Ingestion on the Pharmacokinetics of Talinolol in Healthy Chinese Volunteers“The Cmax of talinolol increased by 51% (90% CI = 21–89%; p = 0.007) with SchE treatment and by 33% (90% CI = 18–51%; p = 0.002) with GBE treatment, respectively.”
“The t1/2 of talinolol increased by 7% (90% CI = −4% to 19%; p = 0.320) with SchE treatment and by 11% (90% CI = −12% to 38%; p = 0.436) with GBE treatment, respectively.”
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