Possible Interaction: Tacrolimus and Calcium Supplement

“In cultured mouse DRG neurons, tacrolimus evokes an increase in intracellular calcium almost exclusively in cold-sensitive neurons, and these responses were drastically blunted in Trpm8 KO mice or after the application of TRPM8 antagonists.”

“While tacrolimus has become the pivotal immunosuppressive agent for individuals with DM-ILD, it has increased the patients’ susceptibility to CA.”

“ Tacrolimus has been shown to effect intracellular calcium and to prolong the action potential duration experimentally.”

“These results indicate that tacrolimus affects calcium and magnesium transport along the distal convoluted tubule and strongly suggests that inhibition of the phosphatase, calcineurin, is directly involved.”

“Results: CsA and tacrolimus induced a 2- to 3-fold and 1.6- to 1.8-fold increase in urinary calcium and magnesium excretion, respectively, while rapamycin had no effects on calcium, but doubled the urinary magnesium excretion.”

“Since it is known that the FK506 binding protein (FKBP12/12.6) interacts with the ryanodine receptor to regulate calcium release, we propose this as the mechanism by which tacrolimus alters intracellular calcium and endothelial nitric oxide synthase rather than by its effect on calcineurin.”

“ Tacrolimus decreased the calcium concentration in the sarcoplasmic reticulum.”