Possible Interaction: Tacrine and Tubocurarine

“Both antagonists were synergistic with the nicotinic agonists in causing up‐regulation, but only d‐tubocurarine showed a synergistic effect with tacrine.”

“The increase in tau immunoreactivity induced by nicotine, epibatidine, and tacrine , but not the up‐regulation of nAChRs, was prevented by the antagonists d‐tubocurarine and mecamylamine.”

“Under these circumstances the effects of both nicotine and tacrine were blocked by (+)tubocurarine (1 μM).These findings demonstrate that tacrine can both inhibit or enhance [3H]acetylcholine release, most likely through its activity as a cholinesterase inhibitor.”

“The neuroprotective effect of tacrine was blocked in the presence of the nicotinic antagonists mecamylamine (10−5 M) and tubocurarine (10−5 M), suggesting an interaction via nicotinic receptors.”

“Chronic THA increased both the ED50 and ED95 of dTC 1.5- to 2-fold (P >or=to 0.05), and this effect tended to decrease with duration of THA therapy.”

“IV THA increased the ED95 of dTC 2.5- to 3-fold (P < 0.05) but did not alter the ED50.”

“ THA was 6-8-fold more potent than verapamil, d-tubocurare , quinidine, and secoverine, the next most effective allosteric agents, and THA was more effective.”