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Last Updated: 3 years ago

Possible Interaction: Sumatriptan and Calcium Supplement

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drug:

Sumatriptan

supplement:

Calcium Supplement

Research Papers that Mention the Interaction

“ Sumatriptan , ketanserin, and granisetron treatment attenuated calcium accumulation and 5HT enhancement of capsaicin‐evoked CGRP release.”

Serotonin increases the functional activity of capsaicin-sensitive rat trigeminal nociceptors via peripheral serotonin receptors

PAIN® • 2011 | View Paper

“We propose that activation of MAPK pathways may increase CGRP gene expression during migraine, and that sumatriptan can diametrically oppose that activation via a prolonged elevation of intracellular calcium.”

Stimulation of the Calcitonin Gene-Related Peptide Enhancer by Mitogen-Activated Protein Kinases and Repression by an Antimigraine Drug in Trigeminal Ganglia Neurons

The Journal of Neuroscience • 2003 | View Paper

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