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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The inhibitory effect of adrenaline was partially blocked by the D2-dopaminergic antagonist sulpiride and totally suppressed by concomitant administration of sulpiride and yohimbine (an alpha 2-adrenergic antagonist).”
Adrenergic control of alpha-melanocyte-stimulating hormone release in frog pituitary is mediated by both beta- and a nonconventional alpha 2-subtype of adrenoreceptors.“In the presence of yohimbine , inhibition by N-0923 (10(-9) to 10(-6) M) of stimulation-evoked contractile responses correlated well with inhibition of tritium efflux, effects which were antagonized by sulpiride.”
“The combination of sulpiride plus yohimbine injected i.c.m.”
“ Sulpiride (1 × 10−6 m) was without effect … little effect on stimulation‐evoked overflow but yohimbine enhanced it approximately 2 fold; the effect of yohimbine was similar at concentrations of 1 × 10−7 … abolished the inhibitory effect of dopamine on stimulation‐evoked overflow, but was without effect against noradrenaline.”
“Since yohimbine prevented the facilitatory action of sulpiride , an analysis of the ability of sulpiride to antagonize alpha-adrenoceptors was made.”
“This effect could be inhibited not only by neuroleptics, such as pimozide or sulpiride , but was also partly antagonized by the α-adrenergic antagonists, yohimbine and piperoxane.”
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