Possible Interaction: Sulforaphane and Doxorubicin Hydrochloride

“Co-administration of SFN and DOX was more efficacious for the treatment of breast cancer in a mouse model than either agent alone, as evidenced by the significant decrease in tumor volume, MDSC expansion, and increase in cytotoxic CD8+ T cells.”

“In nude mice, the combination of sulforaphane and doxorubicin displayed a greater inhibitory effect on MDA‐MB‐231 xenografts growth as compared to either treatment alone.”

“ Sulforaphane and doxorubicin combination exhibited a synergistic inhibition on TNBC cells growth.”

“Additionally, SFN enhanced mitochondrial respiration in the hearts of DOX-treated rats and reduced cardiac oxidative stress caused by DOX , as evidenced by the inhibition of lipid peroxidation, the activation of NF-E2-related factor 2 (Nrf2) and associated antioxidant enzymes.”

“Results of studies in a rat orthotopic breast cancer model indicated that SFN enhanced the efficacy of DOX in regression of tumor growth, and that the DOX dosage required to treat the tumor could be reduced when SFN was administered concomitantly.”

“These studies indicate that SFN not only acts synergistically with DOX in cancer regression, but also protects the heart from DOX toxicity through Nrf2 activation and protection of mitochondrial integrity and functions.”

“The association of sulforaphane– doxorubicin may therefore allow doxorubicin to be administered at lower doses, thereby reducing its potential toxicity.”

“As to the cytotoxic relevance of the RNA damage, we found that the treatment of cells with a mixture of spermine or doxorubicin plus SFN increased their proapoptotic potential.”

“When doxorubicin was used in conjunction with SFN , there was a protective effect to doxorubicin-induced cytotoxicity in D17 and OS 2.4 cells.”

“Taken together, the findings of this study demonstrate that sulforaphane prevents doxorubicin-induced oxidative stress and cell death in H9c2 cells through the induction of HO-1 expression.”

“The respiratory function of cardiac mitochondria isolated from mice exposed to DOX alone was repressed, while SFN treatment with DOX significantly elevated mitochondrial respiratory complex activities.”

“Although cisplatin (CIS), gemcitabine (GEM), doxorubicin , 5-flurouracil, or SF effectively induced apoptosis and prevented viability, combination of a drug with SF increased toxicity.”