Possible Interaction: Sulfinpyrazone and Ascorbate

“Ascorbate re-uptake occurred on the SVCT2, since its blockade by replacing medium sodium with choline, by the SVCT2 inhibitor sulfinpyrazone , or by extracellular ascorbate accelerated ascorbate loss from the cells.”

“Further, transport of the vitamin generated intracellular ascorbate concentrations that were 80-100-fold higher than concentrations in the medium following overnight culture, and transport inhibition with sulfinpyrazone and phloretin partially prevented such ascorbate accumulation.”

“DIDS and sulfinpyrazone , an inhibitor of the urate/lactate exchanger, both significantly reduced the initial rate of ascorbate uptake.”