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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Sulfinpyrazone and Ascorbate

supplement:

Ascorbate

Research Papers that Mention the Interaction

Ascorbate re-uptake occurred on the SVCT2, since its blockade by replacing medium sodium with choline, by the SVCT2 inhibitor sulfinpyrazone , or by extracellular ascorbate accelerated ascorbate loss from the cells.
BioFactors  •  2015  |  View Paper
Further, transport of the vitamin generated intracellular ascorbate concentrations that were 80-100-fold higher than concentrations in the medium following overnight culture, and transport inhibition with sulfinpyrazone and phloretin partially prevented such ascorbate accumulation.
Archives of biochemistry and biophysics  •  2005  |  View Paper
DIDS and sulfinpyrazone , an inhibitor of the urate/lactate exchanger, both significantly reduced the initial rate of ascorbate uptake.
The Journal of nutrition  •  2000  |  View Paper