Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 months ago

Possible Interaction: Sulfinpyrazone and Ascorbate



Research Papers that Mention the Interaction

Ascorbate re-uptake occurred on the SVCT2, since its blockade by replacing medium sodium with choline, by the SVCT2 inhibitor sulfinpyrazone , or by extracellular ascorbate accelerated ascorbate loss from the cells.
BioFactors  •  2015  |  View Paper
Further, transport of the vitamin generated intracellular ascorbate concentrations that were 80-100-fold higher than concentrations in the medium following overnight culture, and transport inhibition with sulfinpyrazone and phloretin partially prevented such ascorbate accumulation.
Archives of biochemistry and biophysics  •  2005  |  View Paper
DIDS and sulfinpyrazone , an inhibitor of the urate/lactate exchanger, both significantly reduced the initial rate of ascorbate uptake.
The Journal of nutrition  •  2000  |  View Paper