“Here, we hypothesized that targeting the Xc− transporter via SAS may improve the anti-cancer activity of VC through regulating GSH biosynthesis, which in turn may result in the accumulation of reactive oxygen species (ROS).”
“The synergistic effect of SAS and VC was also noted in prostate cancer xenografts and correlated with immunohistochemistry results.”
“We also found that the synergistic effect of SAS and VC led to significant cellular GSH depletion, resulting in increased ROS accumulation.”
“We found that SAS could potentiate the short- and long-term cytotoxicity of VC in prostate cancer cells.”