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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Sulfamethoxazole
supplement:
Vitamin C
Research Papers that Mention the Interaction
“The formation of these adducts with SMX was increased in the presence of ascorbic acid , whereas N-acetylcysteine decreased adduct formation with both SMX and DDS.”
Characterization of the Formation and Localization of Sulfamethoxazole and Dapsone-Associated Drug-Protein Adducts in Human Epidermal Keratinocytes“We hypothesized that deficiencies in AA and GSH would enhance drug-tissue adduct formation and immunogenicity toward SMX-NO and that these antioxidant deficiencies might also impair the activity of the b5/b5R pathway.”
Combined ascorbate and glutathione deficiency leads to decreased cytochrome b5 expression and impaired reduction of sulfamethoxazole hydroxylamine
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