Possible Interaction: Succinylcholine and Tubocurarine

“Pretreatment with d-tubocurarine , vecuronium, and pancuronium significantly and equally attenuated both the fasciculations and the cardiovascular responses to succinylcholine.”

“It is concluded that dTC , 0.05 mg/kg, given 3 min before succinylcholine , decreases the potency of succinylcholine by almost 50% and abolishes succinylcholine-associated twitch augmentation.”

“Subparalyzing doses of d-tubocurarine (dTC) given before succinylcholine decrease the duration of neuromuscular blockade.”

“When preceded by a sub-paralysing dose of tubocurarine, suxamethonium produced an increase in masseter tension (47 (SEM 15) g) similar to that produced by suxamethonium alone (59 (13) g).”

“A comparison was made of the incidence of postoperative myalgia (POM) and fasciculations when atracurium (ATR) or d-Tubocurarine (DTC) was given prior to succinylcholine (SDC) for facilitation of tracheal intubation.”

“We compared the incidence of postoperative myalgia (POM) and fasciculations when atracurium (ATR) or d-tubocurarine (DTC) was given prior to succinylcholine (SDC) for tracheal intubation in 44 ASA class I or II outpatient females undergoing laparoscopy.”

“ d‐Tubocurarine and alcuronium pretreatments seemed to attenuate the blood pressure increase during laryngoscopy and intubation under suxamethonium.”

“ Tubocurarine prolonged the onset and shortened the duration of the succinylcholine block and thus made intubation more difficult.”

“Erythematous skin reactions were seen mostly after the use of d-tubocurarine and suxamethonium.”

“The use of d-tubocurarine necessitated a significantly greater amount of suxamethonium to maintain paralysis.”

“The … of suxamethonium (0.58 mg/sec) on the recorded thumb adduction in response to supramaximal ulnar nerve … control subjects: infusion time for 50% block was 37.7 (+/- SEM 1.02) sec. Tubocurarine 3 mg and 6 mg increased the infusion time … by 33.4 and 54.8% respectively.”