Possible Interaction: Succinylcholine and Calcium Supplement

“The decrease in the total calcium concentration may have been caused by the depolarizing action of suxamethonium leading to the migration of the calcium ions into the muscle cells.”

“When Ca++ was omitted from the bathing medium the contractures induced in human vastus lateralis by halothane (three per cent) or succinylcholine (50 mM) were reduced by 80 and 100 per cent, respectively, while contractures induced by caffeine (8 mM) were only reduced by 50 per cent.”

“Volatile anesthetics and/or succinylcholine lead to an increase of the intracellular calcium concentration resulting in activation of various intracellular processes.”

“In low Ca++ or high Mg++ solutions they accentuated SCh blockade and acted as partial agonists.”

“At higher concentrations, procaine, pancuronium and succinylcholine inhibited CICR , but ketamine rather potentiated it.”

“At higher concentrations, procaine, pancuronium and succinylcholine inhibited CICR , but ketamine rather potentiated it.”

“ Calcium alone exhibited an inhibitory effect on the enzyme, but a biphasic effect together with succinylcholine : marked restoration of the enzyme activity at calcium concentrations lower than 6 mM and depression at its higher concentrations.”

“It is suggested that calcium induces a conformational change of the enzyme protein leading to the altered binding capacity of succinylcholine.”