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“Stimulation with substance P resulted in a rapid dose-dependent reduction of [3H]phosphatidylinositol 4,5-bisphosphate and [3H]phosphatidylinositol 4-phosphate, correlated with a rapid accumulation of inositol 1,4,5-triphosphate.”
“In Ca(2+)-free medium, the basal level of [3H]-IPs accumulation was smaller than that in normal medium, and neurokinin A and substance P significantly increased PIP2 hydrolysis.”
Japanese journal of pharmacology • 1992 | View Paper
“These results are consistent with the view that substance P stimulates phosphatidylinositol‐4,5‐bisphosphate ( PIP2 ) hydrolysis of keratinocytes, resulting in IP3‐Ca2+ and diacylglycerol‐protein kinase C signal activation.”
The British journal of dermatology • 1992 | View Paper
“The breakdown of both [32P]… 4-monophosphate ([32P]PIP) and [32P]phosphatidylinositol 4,5-bisphosphate ([32P]PIP2) stimulated … 1 microM substance P significantly increased from 5 to 20 min and returned to basal levels by 30 …; however, the breakdown of [32P]PIP2 was greater than that of [32P]PIP.”