Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Substance P and Phosphatidylinositol 4,5-Diphosphate

Research Papers that Mention the Interaction

Stimulation with substance P resulted in a rapid dose-dependent reduction of [3H]phosphatidylinositol 4,5-bisphosphate and [3H]phosphatidylinositol 4-phosphate, correlated with a rapid accumulation of inositol 1,4,5-triphosphate.
Developmental biology  •  1995  |  View Paper
In Ca(2+)-free medium, the basal level of [3H]-IPs accumulation was smaller than that in normal medium, and neurokinin A and substance P significantly increased PIP2 hydrolysis.
Japanese journal of pharmacology  •  1992  |  View Paper
These results are consistent with the view that substance P stimulates phosphatidylinositol‐4,5‐bisphosphate ( PIP2 ) hydrolysis of keratinocytes, resulting in IP3‐Ca2+ and diacylglycerol‐protein kinase C signal activation.
The British journal of dermatology  •  1992  |  View Paper
The breakdown of both [32P]… 4-monophosphate ([32P]PIP) and [32P]phosphatidylinositol 4,5-bisphosphate ([32P]PIP2) stimulated … 1 microM substance P significantly increased from 5 to 20 min and returned to basal levels by 30 …; however, the breakdown of [32P]PIP2 was greater than that of [32P]PIP.
European journal of pharmacology  •  1991  |  View Paper
Substance P elicited a rapid breakdown of phosphatidylinositol 4,5-bisphosphate and this response was reduced in the denervated gland.
The Biochemical journal  •  1983  |  View Paper
Substance P inhibited both TPI and PA labelling, whereas beta-endorphin inhibited that of PA without any effect on TPI.
Peptides  •  1982  |  View Paper
Adrenaline, acting on alpha-adrenoceptors, and Substance P also stimulated net loss of PtdIns(4,5)P2.
The Biochemical journal  •  1982  |  View Paper