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Last Updated: 2 years ago

Possible Interaction: Substance P and Citric Acid

supplement:

Citric Acid

Research Papers that Mention the Interaction

Moreover, exposure of …-pigs to substance P (10(-4) …) prior to citric acid challenge (0.6 M) resulted in a significant (P<0.05) enhancement of the citric acid-induced bronchoconstriction … not the citric acid-induced cough (11.7+/-1.8 vs. 12.8+/-1.5; P>0.05).
European journal of pharmacology  •  2005  |  View Paper
Citric acid exposure significantly increased substance P concentration in both broncho-alveolar and tracheal lavage fluids, while it decreased significantly the substance P content in tracheal mucosa.
We conclude that citric acid induces in pigs a release of substance P in the tracheo-bronchial tree, which plays a sensitising role on the cough reflex.
European journal of pharmacology  •  2000  |  View Paper