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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Substance P
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“ SP caused a less pronounced increase in iCa2+ in the human fibroblasts (56%).”
Effects of hormones and cytokines on stimulation of adenylate cyclase and intracellular calcium concentration in human and canine periodontal-ligament fibroblasts.“The … calcium concentration was 5 x 10(-3) mol/L, which seemed to be dose-dependent, but … concentration was 1 x 10(-3) mol/L. In all occasions, the influence of SP on the histamine release by MC in hypertrophic scar (… that in normal skin (NS) (P < 0.01).”
“We show that SP stimulates platelet aggregation, and underlying this is the intracellular mobilization of calcium and degranulation.”
“In addition, we show that the activity of substance P required mobilization of intracellular calcium and formation of reactive oxygen intermediates as second messengers.”
“alpha-Protachykinin released almost all the calcium from intracellular stores, while substance P mobilized only 24 +/- 5% of this calcium pool.”
“Addition of 10(-6)-10(-4) M SP to human peripheral blood mononuclear cells results in a dose-dependent rise in intracellular calcium concentration as determined by FACS analysis.”
“ Substance P reduced the currents carried by calcium by 61% in commissural interneurons and by 31% in motoneurons.”
“Thus the reduction of calcium entry by substance P and the accompanying decrease of the sAHP amplitude, combined with substance P potentiation of currents activated by NMDA, may both contribute to the increase in fictive locomotion frequency.”
Modulation of calcium currents and membrane properties by substance P in the lamprey spinal cord.“These findings indicate that DB exerts anti-inflammatory and analgesic effects by blocking the synthesis and release of substance P through inhibition of COX-2 protein induction and intracellular calcium ion concentration.”
“The stimulation of parotid cells by muscarinic agents or substance P or alpha-adrenergic agents increases the intracellular concentration of calcium to such levels.”
“A SP antagonist blocked the SP-induced suppression of IK+ and ICa2+.”
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