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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Streptozocin
supplement:
Taurine
Research Papers that Mention the Interaction
“Two weeks of STZ-D reduced sciatic motor nerve conduction velocity (NCV) by 23% (P < 0.01), decreased composite nerve blood flow by 38% (P < 0.01), and reduced nerve taurine content by 29% (P < 0.05).”
Depletion of Taurine in Experimental Diabetic Neuropathy: Implications for Nerve Metabolic, Vascular, and Functional Deficits“Increased oxidative stress and increased levels of TNF‐&agr;, IL‐1&bgr; induced by STZ were also significantly attenuated by taurine.”
“ STZ decreased the expression of ChAT in hippocampus which was significantly (p < 0.05) reversed by taurine.”
Chronic treatment with taurine after intracerebroventricular streptozotocin injection improves cognitive dysfunction in rats by modulating oxidative stress, cholinergic functions and neuroinflammation“In conclusion, taurine exerts a certain degree of protective and reconstructive effects on islet cells treated by STZ.”
“The results showed that, the release of insulin from islet cells treated by STZ could be inhibited by taurine , gene expression of insulin, PDX-1 and NeuroD1 in STZ group decreased significantly, which were up-regulated by taurine administration.”
“The present research aims to investigate the inhibition effect of taurine on the apoptosis of pancreatic islet cells induced by Streptozotocin (STZ).”
“The results indicated that taurine could significantly restrain apoptosis of pancreatic islet cells induced by STZ.”
“The results showed that STZ induced a significant increase in apoptotic rate of pancreatic islet cells, up-regulated the expression of bax and Fas and down-regulated the expression of Bcl-2, which were significantly blocked by taurine (P < 0.05).”
“An increased latency and path length was observed in ICV-STZ group animals as compared to sham group animals and these were inhibited significantly in STZ group pre-treated with taurine (50 mg/kg body weight orally once daily for 15 days).”
“The activity of antioxidant enzymes, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, catalase, and superoxide dismutase was decreased in STZ group as compared to sham group and pre-treatment of STZ group with taurine has protected their activities significantly.”
“ STZ induced marked embryopathy (32%) and taurine supplementation offered significant protection (54%).”
“The serum concentration of the branched-chain amino acids (BCAA) increased four-fold, and alanine and taurine decreased by approximately 70% and 50%, respectively, after STZ treatment.”
“Four to 12 weeks after the administration of STZ , the lens opacity in the 4% and 8% taurine treatment groups was markedly delayed as compared with that of the STZ group.”
“Recently an immunohistochemical study showed that taurine protects pancreatic β-cells of rats against destruction by streptozotocin injection in a dose-dependent way7.”
“Therefore, it may be suggested that taurine protect pancreatic beta-cells against destruction by ptozotocin injection in a dose-dependent way.”
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