“Induction … streptozotocin led to a 2-… in urinary excretion of Nepsilon-carboxymethyl-lysine and a 27-fold increase in urinary excretion of methylglyoxal-derived hydroimidazolone Ndelta-(5-hydro-5-methyl-4-…-yl)-ornithine - the latter was decreased by high-dose thiamine therapy that also prevented the development of nephropathy.”