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“Pretreatment of the lymphocytes with the nitrone spin trap, α-(4-pyridil-1-oxide)-N-tert-butylnitrone (POBN) or ebselen , which mimics glutathione peroxidase, or pyrrolidine dithiocarbamate (PDTC) reduced the extent of DNA damage evoked by STZ.”
“This study aimed to investigate if icv STZ administration induces peripheral oxidative stress and the antioxidant action of Ebselen , compared to the reference drug (donepezil), in this sporadic AD model.”