Possible Interaction: Streptomycin and Calcium Supplement

“ Calcium ions antagonized the neuromuscular block of streptomycin rapidly but incompletely.”

“The respiratory depression induced by streptomycin was more or less completely reversed when calcium was administered intravenously from external source.”

“In the response to each of the above stimuli, kanamycin (20 mM) or streptomycin (20 mM) caused a decrease in the histamine release elicited in the presence of extracellular Ca2+ (1 mM), although streptomycin showed the much higher inhibitory potency than kanamycin.”

“Antibiotics tested for potential block of Ca++ uptake included the aminoglycosides neomycin and streptomycin , the lincosamide clindamycin, oxytetracycline and polymyxin B. Drugs were applied in concentrations ranging from 1 to 1000 microM. Uptake of 45Ca was determined during depolarization induced by an elevated K+ concentration (77.5 mM).”

“These data indicate that streptomycin and neomycin block adrenal neurotransmission by interfering with calcium ions at pre- or pre-plus postsynaptic levels depending on the dose and route of administration.”

“The synaptic transmission process was altered by streptomycin but was improved by the high calcium concentration.”

“ Streptomycin competes with calcium ions for the membrane release sites while the intracellular mechanisms of release remain unaffected.”

“Application of the PS via trunk injection or root soaking also eliminated or suppressed the ' Ca.”

“Nerve tetanization, neostigmine and calcium were shown to antagonize streptomycin blockade.”